Biocatalysis in Asymmetric Synthesis

Gonzalo De Gonzalo,Andrés R. Alcántara

• Publisher: Academic Press
• Year: 2024
• ISBN:
  9780443190582
• Topic: Ciencias biológicas
• Subtopic: Biofísica

Biocatalysis in Asymmetric Synthesis, a new volume in the Foundations and Frontiers of Enzymology series, offers an applied discussion of synthesizing biological catalysts using asymmetric synthesis, for applications across research and industry. Here, global experts in the field analyze a wide variety of biocatalysts and their physical states, process conditions for their asymmetric synthesis, solvents required during synthesis, and even downstream procedures for the recovery of final products. The book adopts an interdisciplinary approach, merging fundamental biology and its synthetic applications across industries, with a wide range of practical examples, from directed evolution to biotransformation and production of novel enzymes and non-conventional catalysts. Throughout the book, the impact and application of biocatalysis in sustainable processing is considered in-depth. This book will also help non-experts in biocatalysis to apply this knowledge in their own research, providing a thorough overview of the ways asymmetric biocatalytic approaches may be adapted for different disciplines and downstream products.

• Explores biocatalysts as exquisite catalysts for fine chiral compound synthesis in different reaction media
• Features both foundational overviews and applied, practical examples across research and industry
• Includes chapter contributions from international leaders in the field

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• About the editors
• Preface
• Chapter 1. Introduction to asymmetric synthesis employing biocatalysts
• Chapter 2. Biocatalysis and Green Chemistry: assessing the greenness of enzymatic processes
• Chapter 3. Study of stereocontrol in enzymatic reactions using atomic models and computational methods
• Chapter 4. Control of the activity and enantioselectivity in biocatalyzed procedures: immobilization, medium engineering, and protein engineering
• Chapter 5. Hydrolases and their application in asymmetric synthesis
• Chapter 6. Biocatalysis for the selective reduction of carbonyl groups
• Chapter 7. Synthesis of chiral amines employing imine reductases and reductive aminases
• Chapter 8. Biocatalyzed Carbon–Carbon bond formation in enantioselective synthesis
• Chapter 9. Synthesis of chiral compounds through biooxidations
• Chapter 10. Asymmetric biocatalysis in nonconventional media: neat conditions, eutectic solvents, and supercritical conditions
• Chapter 11. Multienzyme-catalyzed processes in asymmetric synthesis: state of the art and future trends
• Chapter 12. Development of asymmetric biotransformations: flow biocatalysis, photobiocatalysis, and microwave biocatalysis
• Chapter 13. Industrial asymmetric biocatalysis
• Chapter 14. Patents based on biocatalytic methods for the synthesis of valuable chiral compounds
• Index