Biochemistry of Collagens, Laminins and Elastin

Structure, Function and Biomarkers

Morten Karsdal

• Publisher: Academic Press
• Year: 2023
• ISBN:
  9780443156182
• Edition: 3
• Topic: Ciencias biológicas
• Subtopic: Biofísica

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third Edition provides current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of these proteins can result in altered signaling properties of the original extracellular matrix (ECM). Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions with ties to endocrine function, and how this knowledge may be used to modulate various pathologies, including fibrotic disease.

This new edition has been expanded and revised to incorporate recent research advances. Several new chapters explore a range of chronic diseases in which the ECM and collagens, laminin and elastin are central players in disease modulation, including new chapters on lung, skin and intestinal disease, as well as cancers. The new edition also considers emerging analytical technologies that can detect biomarkers of ECM degradation, with discussion of protein quantification and detecting aging of collagens.

• Provides an updated, comprehensive discussion of collagen and related structural proteins
• Contains insights into biochemical interactions and changes to structural composition of proteins in disease states
• Proves the importance of proteins for collagen assembly, function and durability
• Examines details on how collagens play a key role in a range of chronic diseases
• Offers approaches for protein quantification and detection of collagen aging

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of contributors
• Foreword
• Preface
• Acknowledgments
• List of abbreviations
• Introduction
• The collagen history
• Chapter 1. Type I collagen
• Chapter 2. Type II collagen
• Chapter 3. Type III collagen
• Chapter 4. Type IV collagen
• Chapter 5. Type V collagen
• Chapter 6. Type VI collagen
• Chapter 7. Type VII collagen
• Chapter 8. Type VIII collagen
• Chapter 9. Type IX collagen
• Chapter 10. Type X collagen
• Chapter 11. Type XI collagen
• Chapter 12. Type XII collagen
• Chapter 13. Type XIII collagen
• Chapter 14. Type XIV collagen
• Chapter 15. Type XV collagen
• Chapter 16. Type XVI collagen
• Chapter 17. Type XVII collagen
• Chapter 18. Type XVIII collagen
• Chapter 19. Type XIX collagen
• Chapter 20. Type XX collagen
• Chapter 21. Type XXI collagen
• Chapter 22. Type XXII collagen
• Chapter 23. Type XXIII collagen
• Chapter 24. Type XXIV collagen
• Chapter 25. Type XXV collagen
• Chapter 26. Type XXVI collagen
• Chapter 27. Type XXVII collagen
• Chapter 28. Type XXVIII collagen
• Chapter 29. Laminins
• Chapter 30. Elastin
• Chapter 31. Fibronectin
• Chapter 32. The extended family of collagens
• Chapter 33. Collagen receptors
• Chapter 34. Aging—the most important collagen neoepitope?
• Chapter 35. Collagen chaperones
• Chapter 36. Collagen diseases
• Chapter 37. The signals of the extracellular matrix
• Chapter 38. The roles of collagens and fibroblasts in cancer
• Chapter 39. Use of extracellular matrix biomarkers in clinical research
• Chapter 40. Common confounders when evaluating noninvasive protein biomarkers
• Chapter 41. Extracellular matrix and endotypes
• Chapter 42. The extracellular matrix of the skin: systemic diseases with local manifestations
• Chapter 43. The basement membrane and its role in pulmonary disease
• Chapter 44. Collagen remodeling in inflammatory bowel disease
• Chapter 45. ECM biomarkers in population-based cohorts
• Chapter 46. Collagen biomarkers of chronic diseases
• Index