Principles of Human Organs-on-Chips

Masoud Mozafari

• Publisher: Woodhead Publishing
• Year: 2023
• ISBN:
  9780128236109
• Topic: Tecnologia e ingegneria
• Subtopic: Scienza dei materiali

Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.

This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.

Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.

• Describes various microfluidic systems and fabrication methods
• Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more
• Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Contributors
• Foreword
• Preface
• Chapter 1. Techniques and materials for the fabrication of microfluidic devices
• Chapter 2. Critical factors affecting cells behavior in microfluidic chips
• Chapter 3. Cell-based assays on microfluidic chips
• Chapter 4. Cell culture techniques in microfluidic chips
• Chapter 5. Advances in skin-on-a-chip and skin tissue engineering
• Chapter 6. Blood vessels-on-a-chip
• Chapter 7. Liver-on-a-chip
• Chapter 8. Lung-on-a-chip
• Chapter 9. Kidney-on-a-chip
• Chapter 10. Eye-on-a-chip
• Chapter 11. Pancreas-on-a-chip
• Chapter 12. Musculoskeletal tissue-on-a-chip
• Chapter 13. Tumour-on-a-chip
• Index