Diagnostic Molecular Pathology
A Guide to Applied Molecular Testing
- 768 pages
- English
- ePUB (mobile friendly)
- Only available on web
Diagnostic Molecular Pathology
A Guide to Applied Molecular Testing
About This Book
Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease.
- Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more
- Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient
- Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient
- Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- List of contributors
- Preface
- Chapter 1. Introduction to molecular testing in human disease
- Chapter 2. Laboratory approaches in molecular pathology: the polymerase chain reaction
- Chapter 3. Whole-exome and whole-genome sequencing in the molecular diagnostic laboratory
- Chapter 4. Long-read sequencing for metagenomics in microbiology
- Chapter 5. Molecular testing for human immunodeficiency virus
- Chapter 6. Molecular testing in hepatitis virus-related disease
- Chapter 7. Molecular testing for human papillomaviruses
- Chapter 8. Molecular testing for parvoviruses
- Chapter 9. Molecular testing for polyoma viruses
- Chapter 10. Molecular testing for respiratory viruses
- Chapter 11. Molecular testing for diseases associated with bacterial infections
- Chapter 12. Agents associated with sexually transmitted infections
- Chapter 13. Molecular methods for healthcare-acquired infections
- Chapter 14. Molecular testing in emerging infectious diseases
- Chapter 15. Molecular and serological testing in the setting of a global pandemic
- Chapter 16. Noninvasive prenatal screening for fetal aneuploidies
- Chapter 17. Molecular testing in inherited cardiomyopathies
- Chapter 18. Molecular diagnostics for coagulopathies
- Chapter 19. Molecular diagnosis of cystic fibrosis
- Chapter 20. Molecular testing in hemochromatosis
- Chapter 21. Molecular genetics of spinal muscular atrophy
- Chapter 22. Molecular testing in autism spectrum disorder
- Chapter 23. Molecular testing in breast cancer
- Chapter 24. Molecular testing in lung cancer
- Chapter 25. Molecular testing in colorectal cancer
- Chapter 26. Molecular pathology and testing in melanocytic tumors
- Chapter 27. Molecular testing for gliomas
- Chapter 28. Molecular testing in pancreatic cancer
- Chapter 29. Molecular testing in gynecologic cancer
- Chapter 30. The emerging genetic landscape of renal cell carcinoma
- Chapter 31. Molecular testing in thyroid cancer
- Chapter 32. Molecular testing in pediatric cancers
- Chapter 33. Molecular pathogenesis of soft tissue and bone tumors
- Chapter 34. Molecular pathology of gastrointestinal stromal tumors
- Chapter 35. Molecular pathology of hepatocellular carcinoma
- Chapter 36. Molecular testing in myeloproliferative neoplasms
- Chapter 37. Molecular testing in myelodysplastic syndromes
- Chapter 38. Molecular testing in acute myeloid leukemia
- Chapter 39. Molecular testing in the assessment of bone marrow transplant engraftment
- Chapter 40. Pharmacogenomics in cardiovascular disease
- Chapter 41. Personalized medicine for disorders of hemostasis and thrombosis
- Chapter 42. Germline pharmacogenomics in cancer treatment
- Chapter 43. Imaging mass spectrometry in clinical pathology
- Chapter 44. Artificial intelligence and deep learning in molecular testing
- Chapter 45. Nanotechnology for molecular diagnostics
- Chapter 46. Chip-based nanotechnology in the molecular pathology laboratory and beyond
- Chapter 47. Translational and clinical applications of the GeoMx digital spatial profiling platform
- Index