Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of 'Linker Chemistry' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.

The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates
Outlines updated methods and techniques to enumerate conjugation with related case studies
Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

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Yes, you can access Polymer-Drug Conjugates by Jitender Madan,Ashish Baldi,Monika Chaudhary,Neetu Chopra in PDF and/or ePUB format, as well as other popular books in Medicine & Pharmacology. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Academic Press

Year

2023

ISBN

9780323916905

Topic

Medicine

Subtopic

Pharmacology

Cover image
Title page
Table of Contents
Copyright
Dedication
Contributors
Editors
Preface
Acknowledgment
Chapter 1. Drug delivery: The conceptual perspectives and therapeutic applications
Chapter 2. Rational design of linkers in polymer–drug conjugates
Chapter 3. Exploration of polymers in drug delivery: The structural and functional considerations
Chapter 4. Chemistry of conjugation in drug delivery: The prospects of biodegradable bonds in polymer–drug conjugates
Chapter 5. Polymer–drug conjugation using ester and ortho-ester bond: Mechanism, protocols, and applications
Chapter 6. Polymer–drug linking through amide bonds: the chemistry and applications in drug delivery
Chapter 7. Drug–polymer conjugate tailoring by disulfide linkage for controlled and targeted drug delivery
Chapter 8. Thioether linkage chemistry: perspectives and prospects in therapeutic designing
Chapter 9. Drug targeting to cancer cells through stimuli-responsive imine bonds: fascinating aspects of site specificity
Chapter 10. Carbamate–drug conjugates in drug delivery: structural and mechanistic considerations
Chapter 11. Bonding through phosphodiester moiety: Its implications in pharmaceutical modifications
Chapter 12. Enzymatically degradable linkers
Chapter 13. Dendrimer–drug conjugates
Chapter 14. Antibody–drug conjugate: Emerging trend for targeted treatment
Chapter 15. Drug–polymer conjugates: Challenges, opportunities, and future prospects in clinical trials
Index