Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies
eBook - ePub

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

  1. 828 pages
  2. English
  3. ePUB (mobile friendly)
  4. Available on iOS & Android
eBook - ePub

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

Book details
Table of contents
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About This Book

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field.

Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood.

  • Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance
  • Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance
  • Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

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Yes, you can access Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies by Ramasamy Paulmurugan,Tarik F. Massoud in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Biology. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
2021
ISBN
9780128215685
Topic
Biological Sciences
Subtopic
Biology
Index
Biological Sciences

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Cover Image Legend
  6. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy”
  7. About the Series Editor
  8. Aims and Scope of the Volume
  9. About the Volume Editors
  10. Preface
  11. Contributors
  12. Chapter 1: Overview of glioblastoma biological hallmarks and molecular pathology
  13. Chapter 2: Past and present drug treatments for glioblastoma
  14. Chapter 3: Investigational new drugs against glioblastoma
  15. Chapter 4: Molecular mechanisms in temozolomide-resistant glioblastoma
  16. Chapter 5: Glioma stem cells and associated molecular mechanisms in Glioblastoma Chemoresistance
  17. Chapter 6: Signaling in the tumor microenvironment of therapy-resistant glioblastoma
  18. Chapter 7: Intratumoral heterogeneity associated with glioblastoma drug response and resistance
  19. Chapter 8: Role of apoptosis, autophagy, and the unfolded protein response in glioblastoma chemoresistance
  20. Chapter 9: Role of multidrug resistance in glioblastoma chemoresistance_ Focus on ABC transporters
  21. Chapter 10: Role of mitochondrial reactive oxygen species in glioblastoma drug resistance and strategies for therapeutic intervention
  22. Chapter 11: Glioblastoma cell-induced immunosuppression causing chemoresistance
  23. Chapter 12: Role of cell quiescence in glioblastoma cytotoxic resistance and strategies for therapeutic intervention
  24. Chapter 13: The molecular and cellular effects of radiotherapy-induced microenvironment changes on potential chemoresistance in glioblastoma
  25. Chapter 14: Molecular and cellular mechanisms in recurrent glioblastoma chemoresistance
  26. Chapter 15: Role of long noncoding RNAs in temozolomide-resistant glioblastoma
  27. Chapter 16: Mechanisms of glioblastoma resistance to antiangiogenic agents and reversal approaches
  28. Chapter 17: Treatment and resistance of glioblastoma to CAR T-cell immunotherapies
  29. Chapter 18: On-chip analysis of glioblastoma cell chemoresistance
  30. Chapter 19: Three-dimensional in vitro models to study potentiation of glioblastoma resistance by hypoxia
  31. Chapter 20: Chemoresistance mechanisms in mouse models of glioblastoma
  32. Chapter 21: Therapeutic approaches to overcome temozolomide resistance in glioblastoma
  33. Chapter 22: Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma
  34. Chapter 23: Targeting the molecular mechanisms of glioma stem cell resistance to chemotherapy
  35. Chapter 24: Immunotherapy for glioblastoma as a means to overcome resistance to standard therapy
  36. Chapter 25: Role of microRNA therapy in presensitizing glioblastoma cells to temozolomide treatment
  37. Chapter 26: Drug penetration through the blood–brain barrier after radiotherapy: New approaches to bypass glioblastoma chemoresistance
  38. Chapter 27: Nanoparticles beyond the blood-brain barrier for glioblastoma
  39. Chapter 28: Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapy
  40. Chapter 29: p53 supplementation as a targeted cancer gene therapy for glioblastoma
  41. Index