Direct Nose-to-Brain Drug Delivery

Mechanism, Technological Advances, Applications, and Regulatory Updates

Chandrakantsing Pardeshi, Eliana B. Souto

• Publisher: Academic Press
• Year: 2021
• ISBN:
  9780128225233
• Topic: Medicine
• Subtopic: Pharmacology

Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments.

• Explains the targeting approaches for enhanced brain targeting following intranasal drug administration
• Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain
• Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Contributors
• About the editors
• Foreword
• Preface
• Section I: Basic considerations in nose-to-brain drug delivery
• Section II: Nanotechnology and naso-brain drug delivery
• Section III: Carriers for direct nose-to-brain drug delivery
• Section IV: Applications of direct nose-to-brain delivery
• Section V: Technological advances for effective drug administration
• Section VI: Evaluation of direct nose-to-brain drug delivery
• Section VII: Toxicity and regulatory aspects
• Index