Fibroblast Growth Factor 23
eBook - ePub

Fibroblast Growth Factor 23

  1. 376 pages
  2. English
  3. ePUB (mobile friendly)
  4. Only available on web
eBook - ePub

Fibroblast Growth Factor 23

Book details
Table of contents
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About This Book

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23.

  • Provides a comprehensive collection of chapters on the diversity of FGF23's actions
  • Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23
  • Describes FGF23's potential in the clinical setting as a biomarker or even drug target
  • Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

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Yes, you can access Fibroblast Growth Factor 23 by Christian Faul,Kenneth White,Orlando Gutierrez in PDF and/or ePUB format, as well as other popular books in Medicine & Endocrinology & Metabolism. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Elsevier
Year
2021
ISBN
9780128180372
Topic
Medicine
Subtopic
Endocrinology & Metabolism

Table of contents

  1. Cover image
  2. Title page
  3. Table of Contents
  4. Copyright
  5. Contributors
  6. Introduction
  7. Chapter 1. The discovery of FGF23—a historic view: genetic disorders of hypo- and hyperphosphatemia
  8. Chapter 2. FGF23—an established master regulator of phosphate metabolism
  9. Chapter 3. Effects of FGF23 in the distal nephron
  10. Chapter 4. The regulation of FGF23 production in bone and outside of bone
  11. Chapter 5. Endocrine fibroblast growth factors and Klotho
  12. Chapter 6. Klotho-independent actions of FGF23—targets, signal transduction, and cellular effects
  13. Chapter 7. The experimental detection of FGF23 responsiveness in target organs
  14. Chapter 8. FGF23 and bone disease
  15. Chapter 9. FGF23 and kidney disease
  16. Chapter 10. FGF23 and heart and vascular disease
  17. Chapter 11. FGF23 and inflammation, anemia, and iron
  18. Chapter 12. FGF23 and infectious diseases
  19. Chapter 13. Fibroblast growth factor 23 and pulmonary disease
  20. Chapter 14. FGF23 and neurocognitive disorders
  21. Chapter 15. FGF23 as a drug target
  22. Chapter 16. FGF23—resolved issues, remaining controversies, and future questions—a clinician's perspective
  23. Chapter 17. Klotho—the discovery of the FGF23 coreceptor
  24. Chapter 18. Soluble α-klotho—a fibroblast growth factor 23–independent hormone
  25. Chapter 19. Klotho and aging phenotypes
  26. Chapter 20. α-Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
  27. Chapter 21. Structural basis of FGF23 hormone signaling
  28. Chapter 22. Klotho—open questions, controversies, and future perspectives
  29. Chapter 23. Regulation of phosphate in health and disease
  30. Index