- 320 pages
- English
- ePUB (mobile friendly)
- Only available on web
Stem Cells and Aging
About This Book
Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.
With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.
- Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population
- Addresses the effect of time and age on human stem cells
- Includes chapters from contributors exploring the biology of stem cell aging around the globe
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Chapter 1: Theories of stem cell aging
- Chapter 2: Progress in human embryonic stem cell research and aging
- Chapter 3: Stem cell aging and wound healing
- Chapter 4: Stem cells and multiomics approaches in senescence: From benchside to bedside
- Chapter 5: Signaling pathways influencing stem cell self-renewal and differentiation
- Chapter 6: Immunity, stem cells, and aging
- Chapter 7: Aging of hematopoietic stem cells: Insight into mechanisms and consequences
- Chapter 8: Ocular stem cells and aging
- Chapter 9: Skeletal muscle cell aging and stem cells
- Chapter 10: Aging and stability of cardiomyocytes
- Chapter 11: Signaling pathways influencing stem cell self-renewal and differentiationâSpecial emphasis on cardiomyocytes
- Chapter 12: Angiogenesis in aging heartsâCardiac stem cell therapy
- Chapter 13: Gut stem cells: Interplay with immune system, microbiota, and aging
- Chapter 14: Cellular senescence and aging in bone
- Chapter 15: Aging-induced stem cell dysfunction: Molecular mechanisms and potential therapeutic avenues
- Chapter 16: Therapeutic approaches for the treatment of aging-induced stem cell dysfunction
- Chapter 17: Role of biological markers in stem cell aging and its implications in therapeutic processes
- Chapter 18: Alternative stromal cell-based therapies for aging and regeneration
- Chapter 19: Stem cell-based therapeutic strategy in delaying prion disease
- Chapter 20: Traditional medicine for aging-related disorders: Implications for drug discovery
- Index