Twentieth Century Mouse Genetics

A Historical and Scientific Review

Robert P. Erickson

• Publisher: Academic Press
• Year: 2021
• ISBN:
  9780128240175
• Topic: Medicine
• Subtopic: Genetics in Medicine

Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.

• Offers a comprehensive examination of key advances in mouse genetics throughout the 20th century
• Includes updates connecting historic research to ongoing advances
• Authored by a thought-leader in the field

Table of contents

• Cover Image
• Title Page
• Copyright
• Dedication
• Table of Contents
• Preface
• Acknowledgements
• Introduction
• 1 The origins of mouse genetics and the discovery of the T-locus
• 2 The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation
• 3 Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions—an over-the-Century Project
• 4 Developmental genetics and recessive t-lethals
• 5 More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion
• 6 Mutation studies including those targeting the T/t-complex—a century long project
• 7 Immunogenetics and the failed search for t-antigens–from mid-century and continuing to it’s end
• 8 Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion
• 9 The cloning era and the cloning of Brachury and other T/t complex genes
• 10 X-inactivation, epigenetics, and imprinting, including of the T/t complex
• 11 Sex determination, sex differentiation, and the Y chromosome—a mostly last quarter of the century effort
• 12 Pharmacogenetics—a mostly last half of the century effort
• Book Bibliography
• Index