Chesley's Hypertensive Disorders in Pregnancy

Robert N. Taylor, Kirk P. Conrad, Sandra T. Davidge, Anne Cathrine Staff, James M. Roberts

• Publisher: Academic Press
• Year: 2021
• ISBN:
  9780128184189
• Edition: 5
• Topic: Medicine
• Subtopic: Endocrinology & Metabolism

Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.

• Summarizes the most relevant basic and clinical studies on hypertensive disorders of pregnancy, helping researchers and students stay up-to-date
• Discusses the roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia
• Widely acclaimed as an essential scholastic resource and enthusiastically endorsed by clinicians and scientists

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• List of Contributors
• About the Editors
• Prefaces
• Chapter 1. The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy
• Chapter 2. Epidemiology of Hypertensive Disorders in Pregnancy
• Chapter 3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia
• Chapter 4. Preconceptional and Periconceptional Pathways to Preeclampsia
• Chapter 5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies
• Chapter 6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome
• Chapter 7. The Immunology of Preeclampsia
• Chapter 8. Trophoblast Extracellular Vesicles in Preeclampsia
• Chapter 9. Angiogenesis and Preeclampsia
• Chapter 10. Vascular Endothelial Cell Dysfunction in Preeclampsia
• Chapter 11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
• Chapter 12. Cardiometabolic Antecedents of Preeclampsia
• Chapter 13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia
• Chapter 14. The Kidney in Normal Pregnancy and Preeclampsia
• Chapter 15. Salt, Aldosterone, and the Renin–Angiotensin System in Pregnancy
• Chapter 16. Platelets, Coagulation, and the Liver
• Chapter 17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy
• Chapter 18. Prediction and Prevention of Preeclampsia
• Chapter 19. Long-Term Effects of Preeclampsia on Mothers and Offspring
• Chapter 20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets
• Chapter 21. Harmonization of Data and Biobanks for Preeclampsia Research
• Index