The Vasculome

From Many, One

Zorina S. Galis

• Publisher: Academic Press
• Year: 2022
• Print ISBN: 9780128225462
• eBook ISBN: 9780128225479
• Topic: Biological Sciences
• Subtopic: Cardiology
• Index: Biological Sciences

The Vasculome: From Many, One introduces the fundamental bases of the "unity in diversity of the Vasculome, from the coming together of various cell lineages during development, to its deceptively simple solution for architectural design: the efficient interplay of a few types of building blocks supporting key similar functions throughout the body and their highly specialized functional local variations. Specific examples are included to illustrate how the Vasculome is integral to the function and malfunction of different organs, such as the brain or the kidney. Each section is preceded by an introductory summary that will give a high level unified view of the key concepts illustrated in the various chapters in that section. Zorina Galis' The Vasculome was named a finalist in the Clinical Medicine category of the American Association of Publishers' 2023 PROSE Awards. - 2023 PROSE Awards - Winner: Finalist: Clinical Medicine: Association of American Publishers - Brings together leading experts who present the latest biomedical thinking about the vasculature from the integrative perspective of the Vasculome - Challenges traditional real and perceived boundaries within vascular research areas and stimulates new fundamental thinking and medical explorations - Creates the bases for translating the integrative Vasculome concept into improved fundamental and clinical assessment and management of local and systemic contributions of the vasculature in health and disease

Table of contents

• The Vasculome
• Cover
• Companion website
• Title Page
• Copyright Page
• Table of Contents
• Contributors
• Preamble
• Acknowledgment
• List of abbreviations
• Chapter 1 Development of, and environmental impact on, endothelial cell diversity
• Introduction
• Chapter 2 Endothelial cell heterogeneity and plasticity in health and disease—new insights from single-cell studies
• Introduction
• Chapter 3 The remarkable diversity of vascular smooth muscle in development and disease
• Introduction
• Chapter 4 Smooth muscle diversity in the vascular system
• Introduction
• Chapter 5 Resident vascular immune cells in health and atherosclerotic disease
• Macrophages
• Chapter 6 Perivascular adipose tissue
• Introduction
• Chapter 7 Major vascular ECM components, differential distribution supporting structure, and functions of the vasculome
• Structure and function of the vasculome
• Chapter 8 Out to the tissues
• Introduction
• Chapter 9 Capillary diversity
• Introduction
• Chapter 10 The neurovascular unit and blood–CNS barriers in health and disease
• The neurovascular unit and the blood–CNS barrier in the healthy state
• Chapter 11 Lymphatic biology and medicine
• Introduction
• Chapter 12 The flow-dependent endotheliome
• Introduction
• Chapter 13 Intravital photoacoustic microscopy of microvascular function and oxygen metabolism
• Introduction
• Chapter 14 Systems biology modeling of endothelial cell and macrophage signaling in angiogenesis in human diseases
• Introduction
• Chapter 15 Simulation of blood flow and oxygen transport in vascular networks
• Introduction
• Chapter 16 Clinical investigations of vascular function
• Vascular endothelial function
• Chapter 17 Angiodiversity—A tale retold by comparative transcriptomics
• Introduction
• Chapter 18 Using pattern recognition and discriminant analysis of functional perfusion data to create “angioprints” for normal and perturbed angiogenic microvascular networks
• Introduction
• Chapter 19 Artificial intelligence for the vasculome
• Introduction
• Chapter 20 Vascular development and organogenesis
• Introduction
• Chapter 21 Normal vascular identity (arteries, veins, and lymphatics) and malformations
• Introduction
• Chapter 22 Sprouting angiogenesis in vascular and lymphatic development
• Vascular development
• Chapter 23 Enablers and drivers of vascular remodeling
• Introduction
• Chapter 24 Extracellular matrix dynamics and contribution to vascular pathologies
• Chapter 25 Lymphatic vascular anomalies and dysfunction
• Introduction
• Chapter 26 Endothelial dysfunction: basis for many local and systemic conditions
• Introduction
• Chapter 27 The vascular phenotype in hypertension
• Introduction
• Chapter 28 Functional roles of lymphatics in health and disease
• Introduction
• Chapter 29 Extracellular matrix genetics of thoracic and abdominal aortic diseases
• Thoracic aortic aneurysms predispose to acute aortic dissections
• Chapter 30 Peripheral arterial disease (pathophysiology, presentation, prevention/management)
• Introduction
• Chapter 31 Venous diseases including thromboembolic phenomena
• Venous thrombogenesis with special emphasis on selectins
• Chapter 32 Targeting vascular zip codes
• Introduction
• Chapter 33 Angiosome concept for vascular interventions
• Introduction
• Chapter 34 RNA therapies for cardiovascular disease
• Introduction to RNA therapeutics
• Chapter 35 The brain vasculome
• Introduction
• Chapter 36 Vasculome
• Chapter 37 The Vasculome provides a body-wide cellular positioning system and functional barometer. The “Vasculature as Common Coordinate Frame (VCCF)” concept
• Key requirements for a common coordinate frame (CCF) for the human body
• Index
• Index - Continued