Biotechnology of Microbial Enzymes

Production, Biocatalysis, and Industrial Applications

Goutam Brahmachari

• Publisher: Academic Press
• Year: 2023
• ISBN:
  9780443190605
• Edition: 2
• Topic: Biological Sciences
• Subtopic: Biochemistry
• Index: Biological Sciences

Biotechnology of Microbial Enzymes: Production, Biocatalysis, and Industrial Applications, Second Edition provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions.

The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last three decades have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book.

This fully revised, second edition is updated to address the latest research developments and applications in the field, from microbial enzymes recently applied in drug discovery to penicillin biosynthetic enzymes and penicillin acylase, xylose reductase, and microbial enzymes used in antitubercular drug design. Across the chapters, the use of microbial enzymes in sustainable development and production processes is fully considered, with recent successes and ongoing challenges highlighted.

• Explores advances in microbial enzymes from basic science through application in multiple industry sectors
• Includes up-to-date discussions of metabolic pathway engineering, metagenomic screening, microbial genomes, extremophiles, rational design, directed evolution, and more
• Provides a holistic approach to the research of microbial enzymes and their use in sustainable processes and innovation
• Features all new chapters discussing microbial enzyme classes of growing interest, as well as enzymes recently applied in drug discovery and other applications

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Dedication
• List of contributors
• About the editor
• Preface
• Chapter 1. Biotechnology of microbial enzymes: production, biocatalysis, and industrial applications—an overview
• Chapter 2. Useful microbial enzymes—an introduction
• Chapter 3. Production, purification, and application of microbial enzymes
• Chapter 4. Solid-state fermentation for the production of microbial cellulases
• Chapter 5. Hyperthermophilic subtilisin-like proteases from Thermococcus kodakarensis
• Chapter 6. Enzymes from basidiomycetes—peculiar and efficient tools for biotechnology
• Chapter 7. Metagenomics and new enzymes for the bioeconomy to 2030
• Chapter 8. Enzymatic biosynthesis of β-lactam antibiotics
• Chapter 9. Insights into the molecular mechanisms of β-lactam antibiotic synthesizing and modifying enzymes in fungi
• Chapter 10. Role of glycosyltransferases in the biosynthesis of antibiotics
• Chapter 11. Relevance of microbial glucokinases
• Chapter 12. Myctobacterium tuberculosis DapA as a target for antitubercular drug design
• Chapter 13. Lipase-catalyzed organic transformations: a recent update
• Chapter 14. Tyrosinase and Oxygenases: Fundamentals and Applications
• Chapter 15. Application of microbial enzymes as drugs in human therapy and healthcare
• Chapter 16. Microbial enzymes in pharmaceutical industry
• Chapter 17. Microbial enzymes of use in industry
• Chapter 18. Microbial enzymes used in food industry
• Chapter 19. Carbohydrases: a class of all-pervasive industrial biocatalysts
• Chapter 20. Role of microbial enzymes in agricultural industry
• Chapter 21. Opportunities and challenges for the production of fuels and chemicals: materials and processes for biorefineries
• Chapter 22. Use of lipases for the production of biofuels
• Chapter 23. Microbial enzymes used in textile industry
• Chapter 24. Microbial enzymes in bioremediation
• Chapter 25. The role of microbes and enzymes for bioelectricity generation: a belief toward global sustainability
• Chapter 26. Discovery of untapped nonculturable microbes for exploring novel industrial enzymes based on advanced next-generation metagenomic approach
• Index