Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies

Sorin Hostiuc

• Publisher: Academic Press
• Year: 2023
• ISBN:
  9780443190469
• Edition: 2
• Topic: Biological Sciences
• Subtopic: Genetics & Genomics
• Index: Biological Sciences

The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering.

• Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive geneticsContains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology
• Discusses preconception carrier screening, genetic engineering, and the use of CRISPR gene editing, mitochondrial gene replacement therapy, and ethical issues, among others
• Considers ethical aspects of recent advances and new technologies in the field, from organoid development to pharmacogenomics and direct-to-consumer genetic testing

Table of contents

• Cover image
• Title page
• Table of Contents
• Copyright
• Contributors
• Chapter 1: Genomic editing: From human health to the “perfect child”
• Chapter 2: Ethics of mitochondrial gene replacement therapy
• Chapter 3: Reproductive technologies used by same-gender couples
• Chapter 4: Ethical issues raised by multiparents
• Chapter 5: Revisiting the nondirective principle of genetic counseling in prenatal screening
• Chapter 6: Sex selection, gender selection, and sexism
• Chapter 7: The impact of “Big Data” on beginning-of-life issues
• Chapter 8: The moral status of the embryo and its uses: Bioethics and social perceptions
• Chapter 9: Fetal reduction
• Chapter 10: Stem cell therapies for neurodegenerative disorders: An ethical analysis
• Chapter 11: Predictive genetic testing in multifactorial disorders
• Chapter 12: Whole-genome sequencing as a method of prenatal genetic diagnosis: Ethical issues
• Chapter 13: Noninvasive prenatal genetic diagnosis
• Chapter 14: Prenatal testing in low-risk populations: After routinization
• Chapter 15: Using genetics for enhancement (liberal eugenics)
• Chapter 16: Should incidental findings arising from prenatal testing be reported indiscriminately to patients?
• Chapter 17: Third-party sharing of genetic information
• Chapter 18: Cerebral and noncerebral organoids
• Chapter 19: Cognitive enhancement: Bioethical aspects
• Chapter 20: Risks and benefits of direct-to-consumer genetic testing in the reproductive context
• Chapter 21: Genetic immunization: Enhancement or public health measure?
• Index