Principles of Gender-Specific Medicine
Sex and Gender-Specific Biology in the Postgenomic Era
- 930 pages
- English
- ePUB (mobile friendly)
- Only available on web
Principles of Gender-Specific Medicine
Sex and Gender-Specific Biology in the Postgenomic Era
About This Book
Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans.We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine.
- Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care
- Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability
- Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human's physiology
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Table of contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Foreword
- Preface
- Chapter 1: Is there a role for natural selection in sex differences?
- Chapter 2: Spermatozoa selection in the female reproductive tract: The initiation of the battle of the sexes
- Chapter 3: Gender/sex: Shaping identity in infancy and early childhood
- Chapter 4: A gendered brain perspective from structure to brain interactions
- Chapter 5: Sex-specific implications of exposure to an adverse intrauterine environment
- Chapter 6: Mate choice and the genetic imprint of the battle of the sexes
- Chapter 7: Using the exposome to understand the role of the environment in gender- and sex-specific medicine
- Chapter 8: Regulation of gene expression in the brain by sex hormones
- Chapter 9: Sex-specific differences in mitochondrial function and its role in health disparities
- Chapter 10: Sex differences in fetal programming: Antenatal origins of health and disease (AOHD)
- Chapter 11: Sex differences in the brain: Focus on developmental mechanisms
- Chapter 12: Genes, environments, and epigenetics
- Chapter 13: Epigenetics: Mechanisms, theory, and social implications
- Chapter 14: Adipose-derived stem cells: Use in clinical medicine
- Chapter 15: All cells have a sex: Sex chromosome function at the cellular level
- Chapter 16: Best-laid plans: The establishment of biological sex and its susceptibility to genetic and environmental disruption
- Chapter 17: CRISPR technology and its potential role in treating rare imprinting diseases
- Chapter 18: Parental genome and brain functions: The case of genomic imprinting
- Chapter 19: Microbiome: Impact of sex on function and characteristics of gut microbiome
- Chapter 20: Geoepidemiology and the key role of sex chromosomes on autoimmune diseases
- Chapter 21: Molecular mechanisms of sex differences in epilepsy
- Chapter 22: Consideration of biological sex in stem cell therapies
- Chapter 23: Sex and the human brain: Moving beyond the binary
- Chapter 24: Genomic and epigenomic signature at the branch-point among genome, phenome, and sexome in health and disease: A multiomics approach
- Chapter 25: The importance of gender-specific medicine in the pharmaceutical industry, clinical practice, and global health care
- Chapter 26: The neurobiology of gender identity and gender dysphoria
- Chapter 27: Nutritional genomics and biological sex
- Chapter 28: The invaluable contribution of animal models in understanding sex-dependent differences in neuropsychiatric disorders
- Chapter 29: Sexual dimorphism in molecular biology of cancer
- Chapter 30: The importance of expeditionary fitness in optimizing the human commercial spaceflight experience
- Chapter 31: Brain morphological changes associated with sexual orientation
- Chapter 32: The operationalization of gender in medicine
- Chapter 33: Precision medicine: Overview and challenges to clinical implementation
- Chapter 34: Assessment of fall risks in older females and males using an automated smartphone mobility suite
- Chapter 35: Statin therapy and sex hormones
- Chapter 36: Exercise physiology in women and men
- Chapter 37: Cerebral effects of gender-affirming hormone treatments in transgender persons
- Chapter 38: Artificial intelligence in healthcare
- Chapter 39: Trauma and gender in primary care
- Chapter 40: Fertility treatment and preservation in transgender men and women
- Chapter 41: Atrial fibrillation in women
- Chapter 42: Sex differences in COVID-19 susceptibility – Reductionistic and holistic perspectives
- Chapter 43: Sex and gender differences in sleep disorders: An overview
- Chapter 44: Estrogen: Impact on cardiomyocytes and the heart
- Chapter 45: Beyond sex and gender differences: The case for women's health research
- Chapter 46: Measurement and meaning of gender/sex from bench to bedside – And the mutuality of equity and precision in medicine
- Chapter 47: Person-centered cancer genetic counseling for transgender and gender diverse patients
- Chapter 48: Musculoskeletal complaints in male and female instrumental musicians
- Chapter 49: Sex, gender, and pain
- Chapter 50: Influence of gender on the pathophysiology and treatment of urological malignancies
- Chapter 51: Beyond the mask: The role of camouflaging in managing an autistic identity for girls and women
- Chapter 52: There is no stronger sex: Evolutionary Anthropology's conclusion based on the sex-typical susceptibility to stress factors during prenatal development
- Chapter 53: Robots and gender
- Chapter 54: Sex specificity in neonatal diseases
- Chapter 55: Human male and female phenotypes depend on lifestyle (smoking and hormonal contraceptives): Implications for prevention and care
- Index