Physico-Chemical Aspects of Drug Action
Proceedings of the Third International Pharmacological Meeting
- 396 pages
- English
- PDF
- Available on iOS & Android
Physico-Chemical Aspects of Drug Action
Proceedings of the Third International Pharmacological Meeting
About This Book
Physico-Chemical Aspects of Drug Action, Volume 7 covers topics on drug kinetics and the overall physicochemical properties of the drug in relation therewith, and the physicochemical aspects of the drug-receptor interaction, putting emphasis on receptor mechanisms and specific properties required for certain types of drugs in this respect. The book starts with some contributions dealing with various general aspects of drug kinetics followed by some contributions dealing with the relationship between certain physicochemical properties of drug molecules and their action. The text describes the pharmacokinetics and dose-concentration relationships; the time course of the biological response to drugs; and the empirical equations for correlating biological efficiency of organic compounds. The text also describes molecular basis for the action of chemotherapeutic drugs; the structure-activity studies on sulphonamides; and the water extrusion hypothesis. The mathematical treatment of two-point attachment between drug and receptor; the molecular properties and biological activity of catecholamines and certain related compounds; and the structure-activity relationships of diarylcarbinolethers are also considered. The book further tackles quantum mechanically-derived electronic distributions in the conformers of 2-pam; and the molecular basis for the action of certain drugs in the central nervous system. Pharmacologists and chemists will find the book invaluable.
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Table of contents
- Front Cover
- Physico-Chemical Aspects of Drug Action
- Copyright Page
- Table of Contents
- LIST OF AUTHORS AND PARTICIPANTS
- CHAPTER 1. INTRODUCTORY REMARKS
- CHAPTER 2. PHARMACOKINETICS AS A BASIC MEDICAL PROBLEM
- CHAPTER 3. KINETICS AND IMPLICATIONS OF DISSOLUTION RATE. LIMITED GASTROINTESTINAL ABSORPTION OF DRUGS
- CHAPTER 4. PHARMACOKINETICS AND DOSE-CONCENTRATION RELATIONSHIPS
- CHAPTER 5. THE TIME COURSE OF THE BIOLOGICAL RESPONSE TO DRUGS :A MATHEMATICAL TREATMENT
- CHAPTER 6. MPIRICAL EQUATIONS FOR CORRELATING BIOLOGICAL EFFICIENCY OF ORGANIC COMPOUNDS
- CHAPTER 7. THE USE OF SUBSTITUENT CONSTANTS IN STRUCTURE-ACTIVITY STUDIES
- CHAPTER 8. MOLECULAR BASIS FOR THE ACTIO N OF CHEMOTHERAPEUTIC DRUG STRUCTURE-ACTIVITY STUDIES ON SULFONAMIDES
- CHAPTER 9. THE STUDY OF DRUG BINDING SITES BY NUCLEAR MAGNETIC RELAXATION
- CHAPTER 10. PATTERNS OF LIGAND-INDUCED CHANGES ON A RECEPTOR SURFACE : THE WATE EXTRUSION HYPOTHESIS
- CAPTER 11. BIOLOGICAL DRUG PARAMETERS FOR STUDIES OF THE RELATIONSHIP BETWEEN STRUCTURE AND ACTIVITY.
- CHAPTER 12. MATHEMATICAL TREATMENT OF TWO - POINT ATTACHMENT BETWEEN DRUG AND RECEPTOR
- CHAPTER 13. CHEMICAL STRUCTURE AND BIOLOGICAL ACTIVITY. SOME GENERAL PRINCIPLES
- CHAPTER 14. MOLECULAR PROPERTIES AND BIOLOGICAL ACTIVITY OF CATECHOLAMINES AND CERTAIN RELATED COMPOUNDS
- CHAPTER 15. SOMEEL ECTRONIC ASPECTS OF PHARMACOLOGY
- CHAPTER 16. DIARYLCARBINOL ETHERS: STRUCTURE ACTIVITY RELATIONSHIPS. A PHYSICO- CHEMICAL APPROACH
- CHAPTER 17. QUANTUM MECHANICALLY DERIVED ELECTRONIC DISTRIBUTIONS IN THE CONFORMERS OF 2-PAM
- CHAPTER 18. A MOLECULAR BASIS FOR THE ACTION OF CERTAIN DRUGS IN THE CENTRAL NERVOUS SYSTEM1
- INDEX