- 144 pages
- English
- PDF
- Available on iOS & Android
Mechanisms of Chemical Carcinogenesis
About This Book
Mechanisms of Chemical Carcinogenesis provides information pertinent to the fundamental mechanisms of chemical carcinogenesis. This book surveys the interactions of chemical carcinogens with native DNA, the activation of normal cellular sequences, and the transforming role of the activated genes. Organized into seven chapters, this book begins with an overview of the relationship between the incidence of lung cancer and the frequency and duration of cigarette smoking. This text then examines the concept that carcinogens may require metabolic activation before they initiate carcinogenesis. Other chapters consider the structure of the nucleoside adducts resulting from the hydrolysis of salmon-sperm DNA and rat-liver ribosomal RNA. This book discusses as well the persistence of nucleoside analogues in target-tissue nucleic acid. The final chapter deals with mutational theory. This book is a valuable resource for workers involved with cancer research, toxicology, and molecular biology. Specialists in drug development, industrial hygiene and occupational medicine will also find this book useful.
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Table of contents
- Front Cover
- Mechanisms of Chemical Carcinogenesis
- Copyright Page
- Table of Contents
- Dedication
- Preface
- Abbreviations
- Chapter 1. Introduction
- Chapter 2. Activation of chemical carcinogens in the mammal
- Chapter 3. Authenticated interactions with nucleic acid
- Chapter 4. Mechanisms in perspective: biological significance of modified deoxyribonucleoside residues in DNA
- Chapter 5. Mechanisms in perspectives: inhibition of tumour induction
- Chapter 6. Mechanisms in perspective: tumour promotion
- Chapter 7. Standard mutational theory of cancer and the impact of contingent advances in genetics
- Index