Drug Design

Medicinal Chemistry: A Series of Monographs, Vol. 2

E. J. Ariëns

• Publisher: Academic Press
• Year: 2013
• ISBN:
  9781483216041
• Topic: Medicine
• Subtopic: Pharmacology

Drug Design, Volume II covers the design of bioactive compounds interacting with enzymes and playing a role in enzyme synthesis. The book discusses the modulation of pharmacokinetics by molecular manipulation; the factors in the design of reversible and irreversible enzyme inhibitors; and the design of organophosphate and carbamate inhibitors of cholinesterases. The text also describes the design of reactivators for irreversibly blocked acetylcholinesterase; drug design based on the inhibition of protein synthesis in the context of susceptible enzymic reactions; as well as the role of enzymes and their synthesis as a target for antibiotic action. The rational design of antiviral agents; the design of penicillin; the design of peptide hormone analogs; as well as the advances in the design of diuretics are also considered. The book further tackles the design of biologically active steroids; the rational elements in the development of superior neuromuscular blocking agents; and the design of tumor-inhibitory alkylating drugs. Pharmacologists, chemists, and people involved in drug design will find the book invaluable.

Table of contents

• Front Cover
• Drug Design
• Copyright Page
• Table of Contents
• List of Contributors
• Preface
• Introduction
• Contents of Other Volumes
• Chapter 1. Modulation of Pharmacokinetics by Molecular Manipulation
• Chapter 2. Factors in the Design of Reversible and Irreversible Enzyme Inhibitors
• Chapter 3. The Design of Organophosphate and Carbamate Inhibitors of Cholinesterases
• Chapter 4. The Design of Reactivators for Irreversibly Blocked Acetylcholinesterase
• Chapter 5. Inhibition of Protein Biosynthesis: Its Significance in Drug Design
• Chapter 6. Enzymes and Their Synthesis as a Target for Antibiotic Action
• Chapter 7. The Rational Design of Antiviral Agents
• Chapter 8. Design of Penicillins
• Chapter 9. The Design of Peptide Hormone Analogs
• Chapter 10. Recent Advances in the Design of Diuretics
• Chapter 11. Design of Biologically Active Steroids
• Chapter 12. Rational Elements in the Development of Superior Neuromuscular Blocking Agents
• Chapter 13. The Design of Tumor-Inhibitory Alkylating Drugs
• Author Index
• Subject Index