The Receptors

Volume III

P. Michael Conn

• Publisher: Academic Press
• Year: 2014
• ISBN:
  9781483273136
• Topic: Medicine
• Subtopic: Pharmacology

The Receptors, Volume III deals with receptors for interferons, hormones, and growth factors as well as for?-aminobutyric acid, tuftsin, somatomedin, and insulin. Prolactin and nicotine receptors are also considered, along with the protein tyrosine kinase activity of hormone and growth factor receptors. Comprised of 12 chapters, this volume begins with a detailed account of secretory component (SC) as a receptor for polymeric immunoglobulins and the importance of SC-polymeric immunoglobulin A interactions in the mucosal immune system. The discussion then turns to interferon receptors and what is known about the fate of interferons and their receptors after binding; the use of muscimol in ligand-binding studies aimed at characterizing?-aminobutyric acid receptors; and the role of protease nexins in the interaction of proteases with cells and in the regulation of proteolytic activity in the interstitial fluid immediately surrounding cells. Subsequent chapters focus on receptor regulation of phosphoinositides and calcium; effects of phospholipid turnover on receptor function; dynamics of tuftsin receptors; and the structure, function, and regulation of somatomedin receptors. The book also examines the internalization and intracellular processing of insulin receptors before concluding with an analysis of prolactin and nicotine receptors. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Table of contents

• Front Cover
• The Receptors
• Copyright Page
• Table of Contents
• Contributors
• Dedication
• Preface
• Contents of Previous Volumes
• Chapter 1. Secretory Component: The Receptor That Mediates External Secretion of Polymeric Immunoglobulins
• Chapter 2. Interferon Receptors
• Chapter 3. Protein Tyrosine Kinase Activity of Hormone and Growth Factor Receptors
• Chapter 4. Muscimol and Central Nervous System y-Aminobutyric Acid Receptors: Studies with Ligand-Binding Techniques
• Chapter 5. Protease Nexins: Secreted Protease Inhibitors That Regulate Protease Activity at or near the Cell Surface
• Chapter 6. Receptor Regulation of Phosphoinositides and Calcium: A Mechanism for Thyrotropin-Releasing Hormone Action
• Chapter 7. Phospholipid Turnover and Receptor Function
• Chapter 8. The Tuftsin Receptors
• Chapter 9. Somatomedin Receptors: Structure, Function, and Regulation
• Chapter 10. The Internalization and Intracellular Processing of Insulin Receptors
• Chapter 11. The Prolactin Receptor
• Chapter 12. Nicotine Receptors in the Central Nervous System
• Index