The Receptors

Volume II

P. Michael Conn

• Publisher: Academic Press
• Year: 2014
• Print ISBN: 9780121852023
• eBook ISBN: 9781483273686
• Topic: Biological Sciences
• Subtopic: Biology
• Index: Biological Sciences

The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

Table of contents

• Front Cover
• The Receptors
• Copyright Page
• Table of Contents
• Contributors
• Preface
• Contents of Previous Volume
• CHAPTER 1. The Vitamin D Receptor
• CHAPTER 2. On Experimental Discrimination between Alternative Mechanistic Models for the Receptor-Mediated Stimulation of Adenylate Cyclase
• CHAPTER 3. The Role of Microaggregation in Hormone-Receptor-Effector Interactions
• CHAPTER 4. The Ah Receptor: A Biochemical and Biologic Perspective
• CHAPTER 5. Interactions of Animal Viruses with Cell Surface Receptors
• CHAPTER 6. Studies on Insulin Receptors: Implications for Insulin Action
• CHAPTER 7. Size of Neurotransmitter Receptors as Determined by Radiation Inactivation-Target Size Analysis
• CHAPTER 8. α2-Adrenergic Receptors: Apparent Interaction with Multiple Effector Systems
• CHAPTER 9. Protein Glycosylation and Receptor–Ligand Interactions
• CHAPTER 10. Role of Steroid Hormone Receptors in Development and Puberty
• CHAPTER 11. Functions and Regulation of Cell Surface Receptors in Cultured Leydig Tumor Cells
• CHAPTER 12. Somatostatin Receptors in Endocrine Cells
• Index