T-cell Activation in Health and Disease is a collection of papers presented at the "T-cell Activation in Health and Disease—Disorders of Immune Regulation—Infection and Autoimmunity" workshop held in Oxford on September 25-29, 1988. This book discusses the progress occurring in T-cell immunity research. One paper discusses the effects of two interaction clones of T-cells that can define the T-cell immunoregulatory network. Another paper discusses the relationship between connectivity and tolerance of the immune network. This paper then suggests the possibility that autoimmunity arises because self-reactive clones are inadequately connected to the network. Another paper reviews the cell-mediated responses in the synovial fluids, as well as the interaction of rheumatoid arthritis synovial fluid dendritic cells and T lymphocytes. The book also examines why attempts for protective immunity to the HIV virus have not been successful. One article then discusses the goals of immunologic intervention in autoimmune disease by using an approach involving the cellular and cytokine targets and their deployment. This text can prove significant for scientists in the field of pharmacology, cellular biology, and researchers in the field of immunology and infectious diseases.

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Yes, you can access T–cell Activation in Health and Disease by M Feldmann,R Maini,J. N. Woody in PDF and/or ePUB format, as well as other popular books in Medicine & Diseases & Allergies. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Academic Press

Year

2017

ISBN

9781483275581

Topic

Medicine

Subtopic

Diseases & Allergies

Front Cover
T-cell Activation in Health and Disease Disorders of Immune Regulation Infection and Autoimmunity
Copyright Page
Table of Contents
Introduction
Chapter 1. T-cell Clone Anti-clone Interactions. Effects on Suppressor and Helper Activities
Chapter 2. The Relationship Between Connectivity and Tolerance as Revealed by Computer Simulation of the Immune Network: Some Lessons for an Understanding of Autoimmunity
Chapter 3. Subsets of Rat CD4+ T Cells Express Different Variants of the Leukocyte-common Antigen: Functions and Developmental Relationships of the Subsets
Chapter 4. Dendritic Cells in Health and Disease
Chapter 5. Antigen Processing: Current Issues, Exceptional Cases (Thy 1 Alloantigen, MHC Class-II-Restricted Cytolytic T Cells), and Implications for Vaccine Development
Chapter 6. Two Distinct Mechanisms of Interleukin-2 Gene Expression in Human T Lymphocytes
Chapter 7. The 4F2 Heavy Chain Gene: a Molecular Model of Inducible Gene Expression in Human T Cells
Chapter 8. The Importance of the Crystalline Surface Layer Protein Antigens of Rickettsiae in T-cell Immunity
Chapter 9. The Mycobacterial Groel Stress Protein: a Common Target of T-cell Recognition in Infection and Autoimmunity
Chapter 10. T-cell Reactivity in Myasthenia Gravis
Chapter 11. Cloning and Characterization of Genes Coding for Tum –Transplantation Antigens
Chapter 12. The Role of Class II Major Histocompatibility Complex Antigens in Autoimmune Diabetes: Animal Models
Chapter 13. Functional and Phenotypic Properties of T-cell Clones which Regulate IgE Synthesis
Chapter 14. Role of Inter leukin-4 in T-cell Ontogeny: Changes in Cell Surface Phenotype and Lymphokine Production of Immature Thymocytes after Culture with Interleukin-4 and Phorbol Ester
Chapter 15. Early Events in Lymphopoiesis: the Role of Interleukins 1 and 7
Chapter 16. Inappropriate Expression of HLA Class II Molecules in Endocrine Epithelial Cells: The Phenomenon, the New Experimental Data and Comparison with Animal Models
Chapter 17. Intrathyroidal Cytokine Production in Thyroid Disease
Chapter 18. Cytokine Production in Culture by Cells Isolated from the Synovial Membrane
Chapter 19. Virus-induced Autoimmunity: Molecular Mimicry as a Route to Autoimmune Disease
Chapter 20. Molecular Dissection of an Antigen-specific Immune Response
Chapter 21. Frequency of VH-gene Utilization in Human EBV-transformed B-cell Lines: The Most JH-proximal VH Segment Encodes Autoantibodies
Chapter 22. A Role for MHC Class II Antigens in B-cell Activation
Chapter 23. Are Ly-1 B Cells Important in Autoimmune Disease?
Chapter 24. 'Fetal-type' B and T Lymphocytes in Rheumatoid Arthritis and Primary Sjögren's Syndrome
Chapter 25. Limitations of the Anti-idiotype Strategy for an HIV Vaccine
Chapter 26. Helper T-cell Determinants in Vaccine Design
Chapter 27. The Goals of Immunologic Intervention in Autoimmune Disease