Metabolic Conjugation and Metabolic Hydrolysis
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Metabolic Conjugation and Metabolic Hydrolysis

Volume I

  1. 508 pages
  2. English
  3. PDF
  4. Only available on web
eBook - PDF

Metabolic Conjugation and Metabolic Hydrolysis

Volume I

Book details
Table of contents
Citations

About This Book

Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminides and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

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Information

Publisher
Academic Press
Year
2014
ISBN
9781483270272
Topic
Biological Sciences
Subtopic
Physiology
Index
Biological Sciences

Table of contents

  1. Front Cover
  2. Metabolic Conjugation and Metabolic Hydrolysis
  3. Copyright Page
  4. Table of Contents
  5. Dedication
  6. LIST OF CONTRIBUTORS
  7. PREFACE
  8. CHAPTER 1. HISTORY OF THE DISCOVERY OF THE CONJUGATION MECHANISMS
  9. CHAPTER 2. NEW METABOLIC CONJUGATES OF STEROIDS
  10. CHAPTER 3.CONJUGATES OF N-HYDROXY COMPOUNDS
  11. CHAPTER 4. EFFECTS OF CONJUGATED STEROIDS ON ENZYMES
  12. CHAPTER 5. GLUCURONIC ACID PATHWAY
  13. CHAPTER 6. SULFOCONJUGATION AND SULFOHYDROLYSIS
  14. CHAPTER 7. GLYCOPROTEIN AND MUCOPOLYSACCHARIDE HYDROLYSIS
  15. CHAPTER 8. HYDROLASES AND CELLULAR DEATH
  16. AUTHOR INDEX
  17. SUBJECT INDEX