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Hormonal Proteins and Peptides
About This Book
Hormonal Proteins and Peptides, Volume I reviews extensively the knowledge on the biology and chemistry of the protein and peptide hormones. This book presents the structures of the various protein and peptide hormones. Organized into five chapters, this volume begins with an overview of the chemistry of several hormonal glycoproteins. This text then presents the research on the purification and chemistry of thyroid-stimulating hormone (TSH). Other chapters consider the study of ovine interstitial cell-stimulating hormone, and concentrate to some extent on the very closely related bovine species. This book discusses as well some aspects of the biology of the pituitary interstitial cell-stimulating hormone or luteinizing hormone in mammalian species. The final chapter deals with the correlation of the primary structure with function for a better understanding of the mechanism of action of the hormone at a molecular level. This book is a valuable resource for biologists, biochemists, and research workers.
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Table of contents
- Front Cover
- Hormonal Proteins and Peptides
- Copyright Page
- Table of Contents
- List of Contributors
- Preface
- Contents of Volume II
- Chapter 1. The Chemistry of Glycoproteins
- Text
- References
- Chapter 2. The Chemistry of Pituitary Thyrotropin
- I. Introduction
- II. Preparation of Bovine TSH
- III. Purification of Human TSH
- IV. The Subunits of Bovine TSH and their Linear Amino Acid Sequences
- V. The Carbohydrate Portion of Bovine TSH
- VI. A Comparison of the Molecular Parameters of Bovine TSH Determined Directly and as Deduced from the Sequence
- VII. The Chemical and Biological Relationships between TSH, LH, and HCG (Human Chorionic Gonadotropin)
- VIII. Comparative StudiesâHuman TSH
- IX. Problems and Possibilities
- Acknowledgments
- References
- Chapter 3. The Chemistry of the Interstitial Cell-Stimulating Hormone of Ovine Pituitary Origin
- I. Introduction
- II. Purification of Ovine ICSH
- III. Physical Properties of Ovine ICSH
- IV. Chemical Properties of Ovine ICSH
- V. The Subunit Nature of ICSH
- VI. Structural Studies on the ICSH Subunits
- VII. Comments on the Heterogeneity of ICSH
- VIII. Concluding Remarks
- Acknowledgments
- References
- Chapter 4. The Biology of Pituitary Interstitial Cell-Stimulating Hormone
- I. Introduction
- II. Gonadotropic Factors of the Pituitary Gland
- III. Biological Effects of ICSH in the Female
- IV. Role of ICSH in Pregnancy
- V. Formation and Maintenance of Corpus Luteum
- VI. Biological Effects of ICSH in the Male
- VII. Extragonadal Actions of ICSH
- VIII. Regulation of ICSH Secretion
- IX. Metabolism of ICSH
- X. Effects of ICSH on Gonadal Metabolism
- XI. Concluding Remarks
- References
- Chapter 5. Chemistry of Human Chorionic Gonadotropin
- I. General
- II. Methods of Purification of HCG
- III. Physicochemical Properties
- IV. Chemical Composition
- V. Amino and Carboxy Terminal Analyses
- VI. Quaternary Structure of HCG
- VII. Investigation of the Carbohydrate Units in HCG
- VIII. Amino Acid Sequence of HCG
- IX. General Considerations
- References
- Chapter 6. Chemistry and Biosynthesis of Thyroid Iodoproteins
- I. Introduction: Definitions and Classifications
- II. Chemistry of Thyroid Iodoproteins
- III. Biosynthesis of Thyroid Iodoproteins
- References
- Author Index
- Subject Index