- 594 pages
- English
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Penicillins and Cephalosporins
About This Book
Chemistry and Biology of?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the?-lactam moiety. This book discusses the occurrence of a group of?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structureâactivity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
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Table of contents
- Front Cover
- Penicillins and Cephalosporins
- Copyright Page
- Table of Contents
- Contributors
- Preface
- Introduction
- Contents of Other Volumes
- Chapter 1. The Chemistry of Penicillin Sulfoxide
- Chapter 2. Cephalosporin Antibiotics Prepared by Modifications at the C-3 Position
- Chapter 3. Cephamycin Antibiotics
- Chapter 4. Antimicrobial and Pharmacokinetic Properties of Newer Penicillins and Cephalosporins
- Chapter 5. Theoretical and Physicochemical Studies on β-Lactam Antibiotics
- Index