Alcohol and Aldehyde Metabolizing Systems, Volume II: Enzymology and Subcellular Organelles contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues ranging from the molecular structure of enzymes to the clinical actions of alcohol in humans. Comprised of 43 chapters, this volume begins by comparing the enzymatically catalyzed oxidation of glyceraldehyde-3-phosphate and lactate, followed by an analysis of liver alcohol dehydrogenase and its mechanism of action. The reader is methodically introduced to the kinetics and mechanism of activated liver alcohol dehydrogenase; structural and functional changes in different alcohol dehydrogenases during evolution; and localization and properties of aldehyde reductase. Subsequent chapters deal with the correlation between the activity of acetaldehyde dehydrogenase and the structure of mitochondria; the distribution of subcellular organelles; and peroxisomes and microsomes. This book will be of value to practitioners and researchers from a variety of disciplines, including biochemistry, physiology, cell biology, and pharmacology.

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Yes, you can access Alcohol and Aldehyde Metabolizing Systems by Ronald G. Thurman,John R. Williamson,Henry R. Drott in PDF and/or ePUB format, as well as other popular books in Ciencias biológicas & Zoología. We have over one million books available in our catalogue for you to explore.

Information

Publisher

Academic Press

Year

2014

ISBN

9781483265469

Topic

Ciencias biológicas

Subtopic

Zoología

Front Cover
Enzymology and Subcellular Organelles
Copyright Page
Table of Contents
LIST OF PARTICIPANTS
PREFACE
CHAPTER 1. A COMPARISON OF THE ENZYMICALLY CATALYZED OXIDATION OF GLYCERALDEHYDE-3-PHOSPHATE AND LACTATE
CHAPTER 2. MECHANISM OF ACTION OF LIVER ALCOHOL DEHYDROGENASE
CHAPTER 3. EXTRAPOLATION OF MECHANISM STUDIES ON GLYCERALDEHYDE-3-PHOSPRATE DEHYDROGENASE TO THE TREATMENT OF AVIAN MUSCULAR DYSTROPHY
CHAPTER 4. KINETICS AND MECHANISM OF ACTIVATED LIVER ALCOHOL DEHYDROGENASE
CHAPTER 5. SOLVENT ISOTOPE EFFECTS IN THE YEAST ALCOHOL DEHYDROGENASE REACTION
CHAPTER 6. KINETICS AND MECHANISM OF ACTIVATED LIVER ALCOHOL DEHYDROGENASE
CHAPTER 7. SOLVENT ISOTOPE EFFECTS IN THE YEAST ALCOHOL DEHYDROGENASE REACTION
CHAPTER 8. KINETICS OF NATIVE AND CHEMICALLY ACTIVATED HUMAN LIVER ALCOHOL DEHYDROGENASES
CHAPTER 9. SUBSTRATE SPECIFICITY AND THE HYDROPHOBIC SITE OF LIVER ALCOHOL DEHYDROGENASE (L-ADH)
CHAPTER 10. PROPERTIES OF HORSE LIVER ALCOHOL DEHYDROGENASE SS
CHAPTER 11. ROOM AND LOW TEMPERATURE SPECTRAL IDENTIFICATION OF THE COBALT BINDINGS SITES IN LIVER ALCOHOL DEHYDROGENASE
CHAPTER 12. HETEROGENEITY IN THE RAPIDLY EXCHANGING METALS OF HORSE LIVER ALCOHOL DEHYDROGENASE
CHAPTER 13. MAGNETIC RESONANCE STUDIES OF THE INTERACTIONS OF IMIDAZOLE AND OTHER LIGANDS WITH COBALT SUBSTITUTED ALCOHOL DEHYDROGENASE FROM LIVER
CHAPTER 14. WATER PROTON RELAXATION AND SPECTRAL STUDIES OF ALCOHOL DEHYDROGENASE PARTIALLY SUBSTITUTED WITH COBALT
CHAPTER 15. INTERACTION AND ACTIVITIES OF NAD+ AND NAD+ ANALOGS WITH FOUR DEHYDROGENASES
CHAPTER 16. MODIFICATION OF TRYPTOPHAN IN LIVER ALCOHOL DEHYDROGENASE
CHAPTER 17. STRUCTURAL AND FUNCTIONAL CHANGES IN DIFFERENT ALCOHOL DEHYDROGENASES DURING EVOLUTION
CHAPTER 18. METAL ΙΟΝ EFFECTORS OF HORSE LIVER ALDEHYDE DEHYDROGENASES
CHAPTER 19. INTERACTION OF DISULFIRAM WITH HORSE LIVER ALDEHYDE DEHYDROGENASE
CHAPTER 20. INTRACELLULAR LOCATION OF 3, 4-DIHYDROXYPHENYLACETALDEHYDE AND ACETALDEHYDE OXIDATION IN RAT LIVER
CHAPTER 21. LOCALIZATION AND PROPERTIES OF ALDEHYDE REDUCTASE
CHAPTER 22. HUMAN LIVER ALDEHYDE DEHYDROGENASE
CHAPTER 23. INHIBITION OF RAT-LIVER ALDEHYDE DEHYDROGENASESIN VITRO AND IN VIVO BY DISULFIRAM, CYANAMIDE AND THEALCOHOL-SENSITIZING COMPOUND COPRINE
CHAPTER 24. CORRELATION BETWEEN THE ACTIVITY OF ACETALDEHYDE DEHYDROGENASE AND THE STRUCTURE OF MITOCHONDRIA
CHAPTER 25. INDUCTION1 OF CYTOSOLIC ALDEHYDE DEHYDROGENASE ISOZYMES: INFLUENCE ON ACETALDEHYDE METABOLISM
CHAPTER 26. THE PLASTIC AND FLUID NATURE OF THE MITOCHONDRIAL ENERGY TRANSDUCING MEMBRANE
CHAPTER 27. PEROXIDE GENERATION IN MITOCHONDRIA AND UTILIZATION BY CATALASE
CHAPTER 28. METABOLISM OF H2O2 AND FATTY ACIDS BY RAT LIVER PEROXISOMES: IMPLICATIONS FOR ETHANOL DETOXIFICATION
CHAPTER 29. SOME EFFECTS OF AGING AND LIPID-LOWERING DRUGSON LIPID METABOLISM AND THE HEPATIC ENDOPLASMIC RETICULUM
CHAPTER 30. ON THE QUESTION OF WHETHER CYTOCHROME P-450 CATALYZES ETHANOL OXIDATION: STUDIES WITH PURIFIED FORMS OF THE CYTOCHROME FROM RABBIT LIVER MICROSOMES
CHAPTER 31. EVIDENCE FOR THE DIRECT INVOLVEMENT OF HEPATIC CYTOCHROME P450 IN ETHANOL METABOLISM
CHAPTER 32. ADVANTAGES OF GAS CHROMATOGRAPHIC DETERMINATION OF ACETALDEHYDE IN STUDIES WITH ETHANOL AND ARECONSTITUTED ENZYME SYSTEM CONTAINING ELECTROPHORETICALLY HOMOGENEOUS PHENOBARBITAL-INDUCIBLE CYTOCHROME P-450 FROM RABBIT LIVER MICROSOMES
CHAPTER 33. RECONSTITUTION OF THE HEPATIC MICROSOMAL ETHANOL OXIDIZING SYSTEM (MEOS) IN CONTROL RATS AND AFTER ETHANOL FEEDING
CHAPTER 34. MICROSOMAL ELECTRON TRANSPORT REACTIONS: THE FORMATION AND UTILIZATION OF HYDROGEN PEROXIDE AS RELATEDTO ALCOHOL METABOLISM
CHAPTER 35. STUDIES ON THE CHARACTERIZATION OF THE ENZYME COMPONENTS PARTICIPATING IN THE HEPATIC-MICROSOMAL OXIDATION OF ALIPHATIC ALCOHOLS
CHAPTER 36. QUANTITATION OF PATHWAYS RESPONSIBLE FOR NADPH-DEPENDENT METHANOL, ETHANOL, AND BUTANOL OXIDATION BY HEPATIC MICROSOMES
CHAPTER 37. CATALASE AND ALCOHOL DEHYDROGENASE-MEDIATED OXIDATION OF ETHANOL IN HEPATIC MICROSOMES OF ACATALASEMIC MICE
CHAPTER 38. ANALYSIS OF MITOCHONDRIAL AND MICROSOMALCYTOCHROMES IN HUMAN LIVER BIOPSY
CHAPTER 39. A NOVEL ROUTE FOR THE METABOLISM OF ETHANOL;THE OXIDATION OF ETHANOL BY HYDROXYL FREE RADICALS
CHAPTER 40. FOLATE DEFICXENCY AND METHANOL POISONING IN THE RAT
CHAPTER 41. THE MONKEY AS A MODEL IN METHANOL POISONING
CHAPTER 42. METHANOL POISONING: ROLE OF FORMATE METABOLISM IN THE MONKEY
CHAPTER 43. MITOCHONDRIAL INJURY IN EXPERIMENTAL CHRONIC ALCOHOLISM
INDEX