Monoamine Oxidases and Their Selective Inhibition
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
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Monoamine Oxidases and Their Selective Inhibition
Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979
About This Book
Monoamine Oxidases and Their Selective Inhibition, Volume IV, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. The discovery of the selective monoamine oxidase (MAO) inhibitors, such as clorgyline and deprenyl, has given a new impetus to MAO research as well as to the clinical applicability of these compounds. This volume contains 21 papers by researchers and clinicians from eight different countries. It begins with papers on the pharmacological effects and the biochemical mode of actions of deprenyl as well as some other new selective inhibitors. This is followed by communications concerning the biochemical methods applied in the study of the nature of MAO in the mitochondrial membrane. Finally, the neurologists provide an account of their experience with the clinical application of deprenyl, and other inhibitors in Parkinsonian patients. They also discuss the essential role of the dopaminergic mechanism with respect to the disease.
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Table of contents
- Front Cover
- Monoamine Oxidases and Their Selective Inhibition
- Copyright Page
- Table of Contents
- PREFACE
- LIST OF CONTRIBUTORS
- CHAPTER 1. THE ANALYSIS OF AMINE OXIDASES BY THE USE OF ENZYMEINHIBITORS
- CHAPTER 2. RECENT CLINICAL STUDIES IN MONOAMINE OXIDASE INHIBITION
- CHAPTER 3. STRUCTURE-ACTIVITY RELATIONSHIP OF SELECTIVE INHIBITORSOF MAO-B
- CHAPTER 4. SELECTIVE INHIBITORS OF MAO-B WITH DIFFERENT PHARMACOLOGICALPROFILES
- CHAPTER 5. 13 METHAMPHETAMINE A THBRAHfiUTIDALLY IMPORTANT METABOLITE OF JSPRENiL?
- CHAPTER 6 . MONOAMINE OXIDASE INHIBrTOIJS (MAOIs) AND FOOD INTAKE
- CHAPTER 7. DEPRENYL INHIBITS DOPAMINE UPTAKE IN THE RAT STRIATUM IN VIVO
- CHAPTER 8. GEL CHROMATOGRAPHY OF PHENYLALKYLAMINES
- CHAPTER 9. Human platelet MAO-B - one single enzyme form?
- CHAPTER 10. SUICIDE INHIBITORS OF MONOAMINE OXIDASE1
- chapter 11. PURIFICATION AND PROPERTIES OP THE PHENYLHYDRAZINE ADDUCTSOP TRIMETHYLAMINE DEHYDROGENASE AND OP MONOAMINE OXIDASE
- CHAPTER 12. SELECTIVE INHIBITION OF MAO INDUCED BY NEW ANTIDEPRESSANTDERIVATIVES OF PYRAZINE-INDOLE
- CHAPTER 13. SELECTIVE INHIBITION OF MONOAMINE OXIDASE TYPE A BY SOME4-AMINOPHENYLISOPROPYLAMINE COMPOUNDS
- CHAPTER 14. THIOL COMPOUNDS AND MDNOAMINE OXIDASE IN RAT LIVER AND BRAIN
- CHAPTER 15. ENZYME STIMULATION AMD INHIBITION AS AN APPROACH TOTHERAPY FOR PARKINSON'S DISEASE
- CHAPTER 16. PHARMACO-THERAPY OF PARKINSONISM
- CHAPTER 17.LINICAL EXPERIENCE IN EXTRAPYRAMIDAL DISEASE WITH SELECTIVEMAO - BINHIBITOR , DEPRENYL
- CHAPTER 18. (-)DEPRENYL HAS A BAND OF SELECTIVITY FOR THERAPEUTIC ACTION
- CHAPTER 19. THE NNACTION OF L- DEPRENYLINL - DOPA TREATED PARKINSONI ANPATIENTS , WITHSPECIAL REFERENCE TO THE1ON- OFF1EF FECT
- CHAPTER 20. LONG-TERM L-DEPRENYL TREATMENT OF ON-OFF PHENOMENA IN PARKINSON'S DISEASE
- CHAPTER 21. LATE KINETIC EFFECTS OF L-DOPA AND COMBINED THERAPYIN PARKINSON'S DISEASE
- SUBJECT INDEX