Alzheimer's Disease Research Guide
eBook - PDF
Available until 21 Sep |Learn more

Alzheimer's Disease Research Guide

Animal Models for Understanding Mechanisms and Medications

  1. 282 pages
  2. English
  3. PDF
  4. Only available on web
eBook - PDF
Available until 21 Sep |Learn more

Alzheimer's Disease Research Guide

Animal Models for Understanding Mechanisms and Medications

Book details
Table of contents
Citations

About This Book

Alzheimer's Disease Research Guide: Animal Models for Understanding Mechanisms and Medications provides researchers with a comprehensive guide, detailing every aspect of Alzheimer's Disease research, including chapters on neuroinflammation, immunotherapy, biomarkers, and animal modeling. This book begins with historical perspectives of both pathological chronology and pathological biochemistry in relation to Alzheimer's disease. Other chapters review Amyloidogenic AB and Non-Amyloidogenic tau and Metabolism of AB major components to the research and understanding of Alzheimer's research. The book concludes with specific treatment chapters including how to develop safe, effective, and inexpensive medications and the application of genome editing to the treatment of Familial Alzheimer's Disease.Written by world renowned expert in Alzheimer's research, this book is a valuable resource for all researchers.

  • Reviews why familial Alzheimer's disease is vital to understanding sporadic Alzheimer's disease
  • Describes the latest "game changer" animal models of Alzheimer's disease and frontotemporal dementia in detail
  • Explains how various Alzheimer's disease medications have failed clinical trials
  • Discusses pros and cons of therapeutic antibodies, lecanemab and donanemab, that were recently found to be effective in recent clinical trials
  • Details the application of genome editing as a treatment for familial Alzheimer's disease
  • Proposes publishing " Journal of Negative Data " for the days of generative AI-assisted publication, AI being unable to distinguish between reproducible and unreproducible data, particularly important in Alzheimer's research

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Yes, you can access Alzheimer's Disease Research Guide by Takaomi C. Saido in PDF and/or ePUB format, as well as other popular books in Biological Sciences & Neuroscience. We have over one million books available in our catalogue for you to explore.

Information

Publisher
Academic Press
Year
2024
ISBN
9780443289804
Topic
Biological Sciences
Subtopic
Neuroscience
Index
Biological Sciences

Table of contents

  1. Front Cover
  2. Alzheimer’s Disease Research Guide: Animal Models for Understanding Mechanisms and Medications
  3. Copyright
  4. Dedication
  5. Contents
  6. Preface
  7. About the author
  8. Abbreviations
  9. Chapter 1: Introduction: Collaboration and competition together to maximize the velocity of research and development
  10. Chapter 2: Pathological chronology and pathological biochemistry: The beginning of the beginning
  11. Chapter 3: Human genetics: Establishment of cause-and-effect relationships
  12. Chapter 4: Two major culprits: Amyloidogenic Aβ and non-amyloidogenic tau
  13. Chapter 5: Exact relationship between Aβ40 and Aβ42: An overlooked discovery by Jungsu Kim and colleagues
  14. Chapter 6: Metabolism of Aβ: Catabolic and glymphatic systems
  15. Chapter 7: Biology of time: The temporal distance between cause and effect
  16. Chapter 8: First-generation animal models of Aβ amyoloidosis: Pros and cons of the overexpression paradigm
  17. Chapter 9: Creation of single App knock-in mouse models and of single MAPT knock-in models: Demonstration of Aβ-tau axis
  18. Chapter 10: Applications of App and MAPT knock-in mice to understanding disease mechanisms
  19. Chapter 11: Neuroinflammation: Microgliosis and astrocytosis in the days of microscopic omics
  20. Chapter 12: Central and peripheral nervous system, immune systems and digestive system: AD as a systemic disorder
  21. Chapter 13: Failure of more than 400 candidate medications in clinical trials before 2020
  22. Chapter 14: Therapeutic antibodies as a Wright Brothers' airplane: Clinical proof-of-concept
  23. Chapter 15: Biomarkers for presymptomatic diagnosis and prognosis
  24. Chapter 16: Targeting somatostatin receptor heterodimer for effective and economically viable medications without side ef ...
  25. Chapter 17: Application of genome editing to the treatment of familial AD
  26. Chapter 18: Identifying significant and insignificant publications: Prelude for Chapter 19
  27. Chapter 19: Journal of Negative Data for the days of generative AI-assisted publication
  28. Chapter 20: Conclusions: Let's make the world ADless!
  29. Eulogy to the late Yasuo Ihara
  30. Postscript
  31. Index
  32. Back Cover