Diabetes and the Kidney

K. N. Lai, S. C. W. Tang

• Publisher: S. Karger
• Year: 2011
• ISBN:
  9783805597432
• Topic: Medicine
• Subtopic: Endocrinology & Metabolism

Caused by an epidemic increase in obesity and diabetes and metabolic syndromes, diabetic nephropathy has become a leading cause of end-stage renal disease in many developed countries. The publication at hand provides a concise overview of the current state of clinical and basic research in the field. It starts with a summary of the epidemiology and genetics of diabetic nephropathy in different ethnic groups, followed by a review of its clinical manifestation, the link with the metabolic syndrome and obesity, and the pathology of diabetic nephropathy. Building on this basis, the latest findings on pathogenetic, epigenetic and inflammatory mechanisms are presented. The publication also looks at advances in the areas of tubulopathy and the kallikrein-kinin system as well as at the latest animal models and the role of lipoproteins and proteomics. This is followed by a discussion of promising therapeutic approaches such as experimental anti-fibrotic strategies, stem cell therapy and pancreatic transplantation; expert reviews on the emerging entity of new onset diabetes after transplantation and the preventive strategies for diabetic nephropathy conclude the material presented.Written by a panel of leading international experts, this book is highly recommended for nephrologists, diabetologists, internist, transplant physicians, scientists, geneticists, epidemiologists and stem cell biologists working in the field of diabetic nephropathy.

Subject Index

Acarbose

ACCORD (Action to Control Cardiovascular Risk in Diabetes) Study

ACE (angiotensin 1-converting enzyme) gene

Acute kidney injury

Acute renal failure

Adhesion molecules

ADIPOQ (adiponectin) gene

Advanced glycation end products

chemical structure

diabetic tubulopathy

dietary intake

epigenetics

formation

inflammatory pathway

natural defenses

pharmacological inhibition

receptors

renal damage

vascular endothelial growth factor induction

ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) Study

AGTR1 (angiotensin II receptor type 1) gene

Akita mutation mice

Alagebrium chloride

Albumin

excretion rate

glycated

serum, elevated filtration

transporters

urinary, see Albuminuria

Albuminuria

biomarker

effect of obesity and metabolic syndrome

murine models

podocytopathies

progression to proteinuria

regression

Aldose reductase

Aldosterone antagonist

Aldosterone axis, kidney

Aldosterone receptor antagonist

Aliskiren

Amadori product

Aminoguanidine (pimagedine)

Amlodipine

Angiogenic factors see also specific factor

Angiopoietins

type 1

type 2

Angiotensin-converting enzyme

Angiotensin-converting enzyme inhibitors

combined with angiotensin receptor blockers

disease progression

oxidative stress

renin-angiotensin system inhibition

renoprotective effects

Angiotensin I

Angiotensin II

Angiotensin II receptors

Angiotensin II subtype-1 receptor

antagonist

Angiotensinogen gene

Angiotensin receptor blockers

combined with angiotensin-converting enzyme inhibitors

oxidative stress

renoprotective effects

Angiotensin-renin system, see Reninangiotensin system

Animal models, see also Murine models

angiogenic factors

dyslipidemia

epigenetics

kallikrein-kinin system activation

kidney regeneration

pancreas transplantation

transforming growth factor-ß/Smad pathway

Animal Models of Diabetic

Complications Consortium

Antibacterial defense proteins

Antifibrotic treatment

advanced glycation end products

inflammatory pathway

novel pathways

profibrotic growth factors

renin-angiotensin-aldosterone system blockade

Antioxidant defense mechanisms

α₁-Antitrypsin

Apical brush border

APOE (apolipoprotein E) gene

Aprotinin

Arteriosclerosis

Bariatric surgery

Benazepril

BENEDICT (Bergamo Nephrologic Diabetes Complications Trial)

Benfotiamine

Betaglycan

Biomarkers, see also specific biomarker

serum

urinary

Blood pressure control

Blood pressure-lowering kinins

Body weight, see Obesity

Bone marrow-derived stem cells

Bone morphogenic protein 7

Bowman's space

Bradykinin

Bradykinin 2 receptor

antagonists

protein

...

Table of contents

• Cover Page
• Front Matter
• Epidemiology of Diabetic Nephropathy
• Genetics of Diabetic Nephropathy in Diverse Ethnic Groups
• Clinical Manifestation and Natural History of Diabetic Nephropathy
• Obesity, Metabolic Syndrome and Diabetic Nephropathy
• Pathology of Human Diabetic Nephropathy
• Pathogenesis and Progression of Proteinuria
• Epigenetic Mechanisms
• Advanced Glycation End Products
• Transforming Growth Factor-β and Smads
• Angiogenic Factors
• Endothelial Nitric Oxide Synthase
• Reactive Oxygen Species and Oxidative Stress
• Inflammatory Pathways
• Diabetic Tubulopathy: An Emerging Entity
• The Renin-Angiotensin System
• The Kallikrein-Kinin System
• Translating Experimental Diabetic Nephropathy Studies from Mice to Men
• Role of Triglyceride-Rich Lipoproteins in Renal Injury
• Study of Diabetic Nephropathy in the Proteomic Era
• Treatment and Landmark Clinical Trials for Renoprotection
• Intensive Glycemic Control and Renal Outcome
• Nuclear Hormone Receptors as Therapeutic Targets
• Antifibrotic Treatment and Other New Strategies for Improving Renal Outcomes
• Kidney Regeneration: Any Prospects?
• Effects of Pancreas Transplantation on the Prevention and Reversal of Diabetic Nephropathy
• New-Onset Diabetes and Nephropathy after Renal Transplantation
• Into the Future: Prevention of Diabetes
• Author Index
• Subject Index