New Trends in Allergy and Atopic Eczema

U. Darsow, H. Behrendt, J. Ring

• Publisher: S. Karger
• Year: 2012
• ISBN:
  9783805598958
• Topic: Medicine
• Subtopic: Pharmacology

Allergy and allergic diseases have increased in prevalence worldwide during the last decade. Relevant determinants influencing the development of allergic inflammation come from the environment and are either enhancing (e.g. environmental pollutants both indoors and outdoors) or protective (e.g. parasite infestations causing early stimulation of the immune system). In spite of considerable progress in experimental allergology and immunology, there is still a great discrepancy between theoretical knowledge and practical performance in the routine treatment of patients with allergies. The development of new therapeutic and preventive strategies for the future management of allergy is dependent on a better understanding of the pathomechanisms and molecular pathways involved. Based on an international symposium, this volume summarizes the latest findings in epidemiology, pathophysiology, and clinical aspects of allergic diseases such as asthma, food allergy, and, especially, atopic eczema. Risk factors for the development of allergies and novel treatment strategies are carefully evaluated. This update is essential reading for anyone interested in allergy: doctors working in the clinical fields of dermatology, pneumology, internal medicine, pediatrics, ENT, epidemiology and public health, as well as researchers in molecular genetics, immunobiology, food and nutrition sciences, and pharmacology.

New Trends in Allergy and Atopic Eczema

Chemical Immunology and Allergy

Vol.96

Series Editors

Johannes Ring Munich

Kurt Blaser Davos

Monique Capron Lille

Judah A. Denburg Hamilton

Stephen T. Holgate Southampton

Gianni Marone Naples

Hirohisa Saito Tokyo

New Trends in Allergy
and Atopic Eczema

Volume Editors

Johannes Ring Munich

Ulf Darsow Munich

Heidrun Behrendt Munich

24 figures, 8 in color, and 6 tables, 2012

Chemical Immunology and Allergy

Formerly published as ‘Progress in Allergy’ (Founded 1939),
continued 1990–2002 as ‘Chemical Immunology’
Edited by Paul Kallós 1939–1988, Byron H. Waksman 1962–2002

_________________________

Prof. Dr. med. Dr. phil. Johannes Ring

Prof. Dr. med. Ulf Darsow

Prof. Dr. med. Heidrun Behrendt

Klinik und Poliklinik für Dermatologie und

Allergologie am Biederstein

ZAUM - Zentrum Allergie und Umwelt

Technische Universität München

Christine Kühne Center of Allergy Research and

Education (CK-CARE)

Biedersteiner Strasse 29

DE–80802 Munich (Germany)

E-Mail [email protected]

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents® and PubMed/MEDLINE.

Disclaimer. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The appearance of advertisements in the book is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.

All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

© Copyright 2012 by S. Karger AG, P.O. Box, CH–4009 Basel (Switzerland)

www.karger.com

Printed in Germany on acid-free and non-aging paper (ISO 9706) by Kraft Druck GmbH, Ettlingen

ISSN 1660–2242

e–ISSN 1662–2898

ISBN 978–3–8055–9894–1

e–ISBN 978–3–8055–9895–8

Contents

Preface

Ring, J.; Darsow, U.; Behrendt, H. (Munich)

Allergy and Environment: Determinants of Allergy Development

Allergy in Evolution

Platts-Mills, T.A.E. (Charlottesville, Va.)

Abstract

Evolution of Protein Structures

‘Evolution’ of Allergic Diseases: 1870–2000

Conclusions

Acknowledgement

References

Climate Change, Environment and Allergy

Behrendt, H.; Ring, J. (Munich)

Abstract

Environment and Allergy

Environmental Pollution

Western Lifestyle

Climate Change

Climate Change Effects upon Pollen

More Pollen

New Polle...

Table of contents

• Cover Page
• Front Material
• Allergy in Evolution
• Climate Change, Environment and Allergy
• The Hygiene Hypothesis Does Not Apply to Atopic Eczema in Childhood
• Molecular Genetics of Atopic Eczema
• Mechanisms of Immune Tolerance to Allergens
• Th17 and Th22 in Skin Allergy
• IL-25 Induces Both Inflammation and Skin Barrier Dysfunction in Atopic Dermatitis
• Angiogenesis, Lymphangiogenesis and Atopic Dermatitis
• What Can Dogs Bring to Atopic Dermatitis Research?
• Can Microbial Superantigens Influence Atopic Dermatitis Flares?
• Inflammation-Induced Alterations in the Skin Barrier Function: Implications in Atopic Dermatitis
• Itch and Eczema
• Eczema Herpeticum
• Bone Mineral Density in Patients with Atopic Dermatitis
• Immunosuppressive Effect of Prolactin-Induced Protein
• Is Food Allergy Testing Reliable in Pediatric Atopic Dermatitis? A Population-Based Study
• New Strategies for Dealing with Staphylococcus aureus Colonization and the Emerging Methicillin-Resistant Staphylococcus aureus Epidemic in Atopic Dermatitis
• Anti-IL-4 as a New Strategy in Allergy
• New Drug Targets in Atopic Dermatitis
• Latest Approaches to Treating Atopic Dermatitis
• Author Index
• Subject Index