Chemogenomics: Knowledge-based Approaches To Drug Discovery
eBook - PDF

Chemogenomics: Knowledge-based Approaches To Drug Discovery

Knowledge-based Approaches to Drug Discovery

Edgar Jacoby

  1. 220 pages
  2. English
  3. PDF
  4. Available on iOS & Android
eBook - PDF

Chemogenomics: Knowledge-based Approaches To Drug Discovery

Knowledge-based Approaches to Drug Discovery

Edgar Jacoby

Book details
Table of contents
Citations

About This Book

In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays.This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided.

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Information

Publisher
ICP
Year
2006
ISBN
9781860948114
Topic
Medicine
Subtopic
Pharmacology

Table of contents

  1. Contents
  2. A Personal Introduction
  3. Chapter 1 Small Molecules for Chemogenomics-based Drug Discovery Edgar Jacoby, Ansgar Schuffenhauer, Kamal Azzaoui, Maxim Popov, Sigmar Dressler, Meir Glick, Jeremy Jenkins, John Davies and Silvio Roggo
  4. Chapter 2 Mapping the Chemogenomic Space Jordi Mestres
  5. Chapter 3 Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development Frank J. Dekker, Stefan Wetzel and Herbert Waldmann
  6. Chapter 4 A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries Roger Crossley and Martin Slater
  7. Chapter 5 In silico Screening of the Protein Structure Repertoire and of Protein Families Didier Rognan
  8. Chapter 6 New Methods for Similarity-based Virtual Screening JĂŠrĂ´me Hert, Peter Willett and David J. Wilton
  9. Chapter 7 Structural Informatics: Chemogenomics In silico Derek A. Debe, Kevin P. Hambly and Joseph F. Danzer
  10. Chapter 8 Construction of a Homogeneous and Informative In vitro Profiling Database for Anticipating the Clinical Effects of Drugs Nicolas Froloff, ValĂŠrie Hamon, Philippe Dupuis, Annie Otto-Bruc, Boryeu Mao, Sandra Merrick and Jacques Migeon
  11. Index
Citation styles for Chemogenomics: Knowledge-based Approaches To Drug Discovery

APA 6 Citation

[author missing]. (2006). Chemogenomics: Knowledge-based Approaches To Drug Discovery ([edition unavailable]). World Scientific Publishing Company. Retrieved from https://www.perlego.com/book/849660/chemogenomics-knowledgebased-approaches-to-drug-discovery-knowledgebased-approaches-to-drug-discovery-pdf (Original work published 2006)

Chicago Citation

[author missing]. (2006) 2006. Chemogenomics: Knowledge-Based Approaches To Drug Discovery. [Edition unavailable]. World Scientific Publishing Company. https://www.perlego.com/book/849660/chemogenomics-knowledgebased-approaches-to-drug-discovery-knowledgebased-approaches-to-drug-discovery-pdf.

Harvard Citation

[author missing] (2006) Chemogenomics: Knowledge-based Approaches To Drug Discovery. [edition unavailable]. World Scientific Publishing Company. Available at: https://www.perlego.com/book/849660/chemogenomics-knowledgebased-approaches-to-drug-discovery-knowledgebased-approaches-to-drug-discovery-pdf (Accessed: 14 October 2022).

MLA 7 Citation

[author missing]. Chemogenomics: Knowledge-Based Approaches To Drug Discovery. [edition unavailable]. World Scientific Publishing Company, 2006. Web. 14 Oct. 2022.